Dose-Escalation and Expansion Study of BGB-16673 (B-Cell Malignancies - RECRUITMENT: OPEN)

Project Title

A Phase 1 Dose-Escalation and Expansion Study of BGB-16673 in Patients With B-Cell Malignancies

Official Title

A Phase 1, Open-Label, Dose-Escalation and -Expansion Study of the Bruton Tyrosine Kinase-Targeted Protein-Degrader BGB-16673 in Patients With B-Cell Malignancies

Project Summary

Study consists of two parts to explore BGB-16673 recommended dosing, a part 1 monotherapy dose finding and a part 2 (cohort expansion in two cohorts)

Blood Disorders

Marginal Zone Lymphoma
Follicular Lymphoma
Mantle Cell Lymphoma
Chronic Lymphocytic Leukaemia
Small Lymphocytic Leukaemia
Waldenstrom's Macroglobulinemia

Patient Recruitment Details

Patient recruitment status: Open

Number of Patients (Globally)

Undetermined.

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What is thrombosis?

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What are DVT & PE?

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Work and Thrombosis

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Antiphospholipid Antibody Syndrome

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Click here to learn more about how certain contraceptives can increase your risk of dangerous blood clots.
Inherited Thrombophilias

Click here for information about genetic conditions that can increase the chances of thrombosis.
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Graham Wild, a passionate 15-year-old boy with a deep love for nature and animals, had dreams of running an animal sanctuary. After returning from a trip to see his dad, Graham started to have trouble breathing and his health rapidly deteriorated. Despite urgent medical attention, his heart stopped, and he couldn't be revived. Graham's mother Kathryn would like to share his story. Read more