Project Title

A Phase 1/2, Open-Label, Dose-Escalation and -Expansion Study of BGB-16673 in Patients with B-Cell Malignancies

Official Title

A Phase 1/2, Open-Label, Dose-Escalation and -Expansion Study of the Bruton Tyrosine Kinase-Targeted Protein-Degrader BGB-16673 in Patients With B-Cell Malignancies

Project Summary

Study consists of two main parts to explore BGB-16673 recommended dosing, a Phase 1 monotherapy dose finding comprised of monotherapy dose escalation and monotherapy safety expansion of selected doses, and a Phase 2 (expansion cohorts).

Blood Disorders

  • Marginal Zone Lymphoma

  • Follicular Lymphoma

  • Mantle Cell Lymphoma

  • Chronic Lymphocytic Leukaemia

  • Small Lymphocytic Leukaemia

  • Waldenstrom's Macroglobulinemia

Patient Recruitment Details

Patient recruitment status: Open

Number of Patients (Globally)

Undetermined.